To make sad, to upset.
with such weak nerves and spirits, and in the condition I am in at present, ’twould be as much as my life was worth, to deject and contrist myself with so bad and melancholy an account
From Old French (and modern French) contrister, from Latin contrīstō, from con- + tristis (“sad”) + -ō (verb-forming suffix). Doublet of contristate.
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