To interact with in a careless or inappropriate way.
Don't fuck with that gang! They all carry guns!
To play with in a lighthearted or joking manner; kid with; play tricks on.
Don't take it serious, man, I'm just fucking with you.
To affect seriously or disturbingly; give someone a hard time; to trouble, harass.
The thought that she might be cheating on me is really fucking with me.
From fuck + with. In some senses, shortened from fuck around + with.
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