Of string or something stringlike: full of, or tied up, in knots.
I could a Tale vnfold, vvhoſe lighteſt vvord / VVould harrovv vp thy ſoule, freeze thy young blood, / Make thy tvvo eyes like Starres, ſtart from their Spheres, / Thy knotty and combined locks to part, / And each particular haire to ſtand an end, / Like Quilles vpon the fretfull Porpentine: […]
Of a part of the body, a tree, etc.: full of knots (knobs or swellings); gnarled, knobbly.
a knotty pine
Complicated or tricky; complex, difficult.
From Middle English knotti, knotty (“having a knot in it; full of knots; tied together (?); resembling a knot, knotlike; having knobs or protuberances; bulging, convex; of a tree, branch, etc.: full o...
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a knotty problem