To release from one's grasp; to go from a state of holding on to a state of no longer holding on.
You're hurting him! Let him go!
To emotionally disengage or distract oneself from a situation.
You are supported, so you can just let go and relax. Inhale and slowly exhale.
To dismiss from employment.
The secretary didn't work out, so her boss told her she was being let go.
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